胶质细胞源神经营养因子,glial cell line-derived neurotrophic factor
1)glial cell line-derived neurotrophic factor胶质细胞源神经营养因子
1.Objective To investigate the neural differentiation potential and expression change of neurotrophic factors-glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) in rat bone marrow stromal cells (BMSC).先以bFGF(10ng/ml)预诱导24h,然后以胶质细胞源神经营养因子(glial cell line-derived neurotrophic factor,GDNF)10ng/ml在胎肠培养基(fetal gut condition midium,FGCM)条件下诱导10d。
2.The article focuses on some factors and their effects on renewal and differentiation of spermatogonial stem cells, including c-kit receptor and its ligand (stem cell factor), leukaemia inhibitory factor, vitamin A, epithelial growth factor,glial cell line-derived neurotrophic factor, hormone and temperature.根据现有资料阐述一些因素,包括c Kit受体及其配体SCF、白血病抑制因子(LIF)、维生素A(VA)、表皮生长因子(EGF)、胶质细胞源神经营养因子(GDNF)、激素和温度,对精原干细胞更新分化的影响。
3.Objective To investigate neural differentiation of rat bone marrow stromal cells(BMSCs) and expression of change ofglial cell line-derived neurotrophic factor(GDNF).目的探讨大鼠骨髓间充质干细胞(BMSCs)神经分化及胶质细胞源神经营养因子(GDNF)表达的变化。
英文短句/例句
1.Cloning and expression ofgllal cell line－derived neurotrophlc;大熊猫和朱鹮胶质细胞源神经营养因子（GDNF）的克隆及表达研究
2.Expression of Glial Cell Line-Derived Neurotrophic Factor during Differentiation of Rat Bone Marrow Stromal Cells into Nerve Cells胶质细胞源神经营养因子在大鼠骨髓间充质干细胞神经分化中的表达
3.Glial cell line-derived neurotrophic factor and neuropathic pain胶质细胞源性神经营养因子与神经病理性疼痛
4.Experimental Study on the Effects of GDNF on Perineural Invasion of Pancreatic Carcinoma胶质细胞源性神经营养因子在胰腺癌神经浸润中作用的实验研究
5.Effect of glial cell-derived neurotrophic factor-modified adipose-derived stem cells on survival of co-cultured dopaminergic neurons胶质细胞系源性神经营养因子修饰脂肪间质干细胞与共培养多巴胺能神经元的存活
6.Identification of the Interaction between Rap1GAP and Glia Cell Line-derived Neurotrophic Factor Receptor Ret胶质细胞源性神经营养因子受体Ret与Rap1GAP相互作用及其功能的研究
7.Expression of GFR-α_1 in cells of subventricular zone of different months old rats不同月龄大鼠脑室下区胶质细胞源性神经营养因子受体α_1的表达
8.Glial Cell Line-derived Neurotrphic Factor Therapy for Spinal Cord Injury: An Experimental Study;胶质细胞源性神经营养因子治疗大鼠脊髓损伤的实验研究
9.Reserch on the Structure-Function of Glial Cell-Line-Derived Neurotrophic Factor Receptor Alpha;胶质细胞源性神经营养因子受体alpha1结构与功能关系的探讨
10.Study on Cloning and Expression of Rat Glial Cell Line-derived Neurotrophic Factor;大鼠胶质细胞源性神经营养因子克隆及表达的研究
11.VaV2 Native Feedback Adjust GDNF EffectVaV2对胶质细胞源性神经营养因子作用的负反馈调节
12.Effects of brain derived neurotrophic factor on growth of human glioma cell line脑源性神经营养因子促进人脑胶质瘤细胞株生长的研究
13.Eukaryotic vector construction of rat gliaI cell-line derived neurotrophic factor大鼠胶质细胞源性神经营养因子真核表达载体的构建
14.The research on the differentiation of dopaminergic neuron from neural stem cell induced by ascorbic acid and glial cell line-derived neurotrophic factor抗坏血酸联合胶质细胞源性神经营养因子诱导神经干细胞向多巴胺能神经元分化的研究
15.Expression of Glial Cell Derived Neurotrophic Factor mRNA and Interstitial Cells of Cajal in Hirschsprung s Disease;胶质细胞源性神经营养因子及Cajal间质细胞在先天性巨结肠中的表达和分布研究
16.Cotransfection of glial cell-derived neurotrophic factor and endothelin receptor type B gene into mouse neural stem cells胶质细胞源性营养因子及内皮素B受体基因共转染小鼠神经干细胞(英文)
17.Study of the cotransfection of GDNF and EDNRB into neural stem cells胶质细胞源性营养因子及内皮素B受体基因共转染神经干细胞实验研究
18.Study on the Expression of GDNF and Its Receptor in Human Gliomas and Their Relations with the Malignancies of Gliomas;胶质细胞源性神经营养因子及其受体在人脑胶质瘤中的表达及意义研究
相关短句/例句
Glial cell line-derived neurotrophic factor(GDNF)胶质细胞源性神经营养因子
1.Using semi-quantity RT-PCR and immunhistochemistry to assay the expression of Glial cell line-derived neurotrophic factor(GDNF)in piglet testes and to investigate the significance of GDNF in the regulation of testes development and spermatogenesis.采用免疫组化(immunohistochemistry)和半定量RT-PCR法研究了胶质细胞源性神经营养因子(Glialcellline-derivedneurotrophicfactor,GDNF)在生后仔猪睾丸中的表达,探讨了GDNF在睾丸发育和精子发生中的作用。
2.Objective To investigate the effect of exogenous glial cell line-derived neurotrophic factor(GDNF) infused into the cavitas subarachnoidealis on spinal front corner motor neurons after sciatic nerve axotomy.目的研究周围神经损伤后,经蛛网膜下腔置管局部应用外源性胶质细胞源性神经营养因子(glial cellline-derived neurotrophic factor,GDNF)对脊髓前角运动神经元的保护作用。
3)glial cell line-derived neurotrophic factor胶质细胞源性神经营养因子
1.Dynamic expression ofglial cell line-derived neurotrophic factor and regulation mechanism of topiramate following hypoxic-ischemic brain damage in neonatal rats;缺氧缺血性脑损伤新生大鼠胶质细胞源性神经营养因子表达及调控机制探讨
2.Distribution ofglial cell line-derived neurotrophic factor in the central nervous system of the adult rhesus;成年恒河猴中枢神经系统胶质细胞源性神经营养因子的分布
3.Experimental study of intracerebral co-graft of neural stem cells andglial cell line-derived neurotrophic factor for treating Parkinson′s disease;神经干细胞联合胶质细胞源性神经营养因子脑内移植治疗帕金森病的实验研究
4)glial cell line-derived neurotrophic factor(GDNF)胶质细胞源性神经营养因子(GDNF)
5)Glial cell line derived neurotrophic factor胶质细胞源性神经营养因子
1.Objective To observe the effects of mesenchymal stem cells (MSCs)injection from tail-vein on the expression of glial cell line derived neurotrophic factor (GDNF) after the spinal cord injury (SCI) of rats.[目的]探讨经静脉移植骨髓间充质干细胞(MSCs)对大鼠脊髓损伤(SCI)后胶质细胞源性神经营养因子(GDNF)表达的影响。
2.Objective To clone the glial cell line derived neurotrophic factor total gene of rat and construct expression of prokaryotic cell.目的克隆大鼠胶质细胞源性神经营养因子 (GDNF)全长基因 ,构建真核细胞表达质粒。
3.Objective: To examine the expression of glial cell line derived neurotrophic factor (GDNF) in injured spinal cord and to observe effect of exogenous GDNF on the regeneration of injured axons.目的 :研究脂质体介导的胶质细胞源性神经营养因子 (GDNF)基因在大鼠损伤脊髓内的表达 ,观察外源性 GDNF对损伤脊髓轴突再生的作用。
6)Glial cell line-derived neurotrophic factor胶质细胞系源性神经营养因子
1.Effect of glial cell line-derived neurotrophic factor on the expressing of calbindin D28K in substantia nigra of rat model of Parkinson s disease;胶质细胞系源性神经营养因子对帕金森病大鼠黑质钙结合蛋白表达的影响
2.ObjectiveTo explore the protective effect of glial cell line-derived neurotrophic factor(GDNF) on injured dopaminergic(DA) neurons and the possible role of neural cell adhesion molecule(NCAM) in this protective process.目的研究胶质细胞系源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)对损伤的多巴胺(dopamine,DA)能神经元的保护作用和神经细胞黏附分子(neural cell adhesion molecule,NCAM)在这一保护过程中的影响。
3.It is known that through binding to the tyrosine kinase receptor RET, the glial cell line-derived neurotrophic factor (GDNF) activates two intracellular signaling pathways: the phosphatidylinositol 3 kinase (PI3K) pathway and the Ras/Raf/MEK/Erk pathway.胶质细胞系源性神经营养因子(GDNF)可以通过跨膜的酪氨酸蛋白激酶受体RET激活细胞内两条信号通路,即磷脂酰肌醇3激酶(PI3K)信号通路和Ras/Raf/MEK/Erk信号通路。
延伸阅读
神经胶质细胞成长因子分子式：CAS号：性质：是一种酸性蛋白，在猪脑中有两种形式，一种高分子量GMF（HMF-GMF），分子量2×105左右，另一种低分子量GMF（LMN-GMF），分子量在4×104左右。前者在脑抽提物中约占85%，后者随冻融的次数增加而升高。牛脑中制得的分子量约1.3×104，生物活性与猪脑的GMF完全相同。它们对多种蛋白酶敏感，加热或PH值较大改变都使其失活。GMF能加快皮样成胶质细胞的分化和成熟程度，在1～2天内使体外培养的上述细胞转变为多角形星状胶质细胞。还能加快体外培养的许旺氏细胞（Schwan cell）的分裂和繁殖速度。可诱发系列生物变化。
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