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银屑病关节炎的治疗

时间:2023-02-18 00:06:19

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银屑病关节炎的治疗

引言

银屑病关节炎(psoriatic arthritis, PsA)的治疗涉及多种干预方法,包括用于治疗其他类型炎症性关节炎[尤其是脊柱关节炎和类风湿关节炎(rheumatoid arthritis, RA)]患者的许多药物,以及其他用于治疗银屑病皮肤表现的方法。

虽然许多药物对RA和PsA都有效,但涉及一些生物制剂类型的试验提示,RA和PsA患者也可能对一些药物类型有显著不同的反应。对PsA不同方面的治疗包括协调干预处理疾病的主要部分,包括外周和中轴性关节炎、附着点炎、指/趾炎以及皮肤和指/趾甲受累。(参见“银屑病关节炎的临床表现和诊断”)

本专题将讨论PsA(包括外周和中轴性关节炎、附着点炎和指/趾炎)的治疗。银屑病相关皮肤和指/趾甲受累的治疗,PsA的临床表现与诊断,以及PsA的发病机制参见其他专题。(参见“成人银屑病的治疗”和“甲银屑病”和“银屑病关节炎的临床表现和诊断”和“银屑病关节炎的发病机制”)

处理原则和处理前干预

治疗方法包括同时针对肌肉骨骼疾病(包括外周和中轴性关节炎、附着点炎和指/趾炎)以及皮肤和指/趾甲疾病的治疗,目的是控制炎症并预防不适、关节损伤和失能[1,2]。个体患者常常有超过一种类型的肌肉骨骼受累,并常有皮肤受累。治疗PsA的一般原则包括:

●由具有诊治风湿性疾病患者专业知识的临床医生进行早期评估和治疗对患者有益[3,4](参见下文‘预后’),治疗应由风湿科医生、初级保健医生和其他专科医生(如,皮肤科医生)协同开展。常观察到皮肤与关节病变对各治疗的反应不同,不同的肌肉骨骼表现对各治疗的反应也不同。

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