美托洛尔,Metoprolol
1)Metoprolol美托洛尔
1.Synthesis ofMetoprolol Catalyzed by Lewis Acid;Lewis酸催化在合成美托洛尔中的应用
2.Preparation of felodipine-metoprolol transdermal patch and its antihypertensive effects in spontaneously hypertensive rats;非洛地平-美托洛尔复方透皮贴剂的研制及其药效实验研究
3.Preparation and Absorption Property of Molecularly Imprinted Polymer forMetoprolol;美托洛尔球形分子烙印聚合物的制备及吸附性能考察
英文短句/例句
1.Synthesis of (S)-Carteolol and (S)-Metoprolol（S）—卡替洛尔与（S）—美托洛尔的合成
2.Clinical Study of Metoprolol in Chronic Heart Failure;美托洛尔治疗慢性心力衰竭临床研究
3.Evaluation of the effect on metoprolol succinate sustdined release tablets in reducing blood pressure琥珀酸美托洛尔缓释片降压效果评价
4.Metoprolol-induced Adverse Drug Reactions of 62 Cases and Analysis of Rational Drug Use美托洛尔62例不良反应及合理用药
5.Effect of amiodarone on pharmacokinetics of metoprolol胺碘酮对美托洛尔药代动力学的影响
6.Studies on Transdermal Drug Delivery System of Felodipine and Metoprolol;非洛地平—美托洛尔复方经皮给药系统的研究
7.Clinical effects of bisoprolol in comparison with metoprolol in hypertensive patients with non-dipper pattern of blood pressure比索洛尔和美托洛尔治疗非杓型高血压患者临床观察
8.Studies on Oral Delayed Onset Drug Delivery System of Metoprolol Fumarate;富马酸美托洛尔延迟起效型口服给药系统研究
9.Left Ventricular Diastolic Function Changes in Hypertension Treated with Metoprolol;美托洛尔对高血压病病人左室松弛性的影响
10.Research and Development of Metoprolol Tartrate Pulsatile Pellets;酒石酸美托洛尔脉冲微丸的研究与开发
11.Metoprolol Contributed Antiarrhythmic Effect of Amiodarone;美托洛尔对胺碘酮抗心律失常增效作用研究
12.The Effect of Metoprolol on Cardiac Function in Patients with Congestive Heart Failure;美托洛尔对充血性心力衰竭患者心功能的影响
13.The Cure Hypertension and Chronic Beautiful Tuoluoer Cardiac Failure Curative Effect Is Observed美托洛尔治疗高血压并慢性心力衰竭疗效观察
14.Determination of Metoprolol tartrate sustained-release matrix tablets by HPLCHPLC法测定酒石酸美托洛尔骨架缓释片的含量
15.Determination the Content and Related Substances of Metoprolol Tartrate Tablets by HPLCHPLC法测定酒石酸美托洛尔片的含量和有关物质
16.Therapeutic effect of metoprolol in patients with chronic congestive heart failure美托洛尔治疗慢性充血性心力衰竭的疗效观察
17.Observation of Effect of Nicardipine Combined with Metoprolol in the Treatment of Renal Hypertension尼卡地平联合美托洛尔治疗肾性高血压观察
18.Clinical observation of therapy effects of metoprolol tablets on chronic heart failure美托洛尔治疗慢性充血性心力衰竭临床观察
相关短句/例句
betaloc美托洛尔
1.Clinic Observation on Blockade Betaloc and Enalapril in Treating Chronic Heart Failure;美托洛尔与依那普利联合治疗慢性心力衰竭临床观察
2.Effects of Betaloc on mRNA Expression of Calcium Release Channels of Myocardial Sarcoplasmic Reticulum in Dysfunctional Heart;美托洛尔对心力衰竭大鼠心肌细胞肌浆网Ca~(2+)释放通道数量及其mRNA表达的影响
3.Intravenousbetaloc in termination of paroxysmal supraventricular tachycardia;静脉注射美托洛尔治疗室上性心动过速疗效观察
3)metoprolol tablet美托洛尔片
4)Metoprolol/metab美托洛尔/代
5)S-metoprololS-美托洛尔
1.Asymmetric synthesis ofS-metoprolol;S-美托洛尔的不对称合成
6)metoprolol tartrate酒石酸美托洛尔
1.Preparation ofmetoprolol tartrate sustained-release pellets;酒石酸美托洛尔缓释微丸的制备及处方因素考察
2.Bioequivalence ofmetoprolol tartrate tablets in healthy volunteers;酒石酸美托洛尔片在健康人体中的生物等效性研究
3.Relative bioavailability ofmetoprolol tartrate extended release tablets;酒石酸美托洛尔缓释片人体相对生物利用度研究
延伸阅读
美托洛尔分子式：C15H25NO3分子量：267.38CAS号：37350-58-6性质：美多心安盐酸盐为白色粒结晶，熔点80-81℃，易溶于水，溶于冰醋酸和乙醇，微溶于苯，不溶于酮。制备方法：以苯乙醇为原料，经醚化得β-甲氧基乙苯，再经硝化，再经硝化、还原、重氮化、水解得4-羟基β-甲氧基乙苯，再与环氧氯丙烷醚化后，与异内胺缩合成盐即得。以苯乙醇计，总收率20-25%。用途：该品作为治疗高血压药物，主要使用其酒石酸盐（C34H56N2O12，[56392-17-7]），也用其盐酸盐。美多心安对β1肾上腺受体有选择性阻断作用，对β2受体作用较弱，较大剂量可使血管及支气管平滑肌收缩，并有较弱的膜稳定剂作用，无内源性拟交感活性。可减慢心率、减低心排出量和心肌耗氧量以及降低血压。主要用于治疗心绞痛及高血压。用于治疗高血压和心绞痛。该品为70年代上市的选择性β-受体阻滞剂。小鼠口服LD50为2193±166mg/kg。
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