piano is her main focus she's also great at guitar.A. SinceB. OnceC. UnlessD. While

问题补充：

piano is her main focus, shes also great at guitar.

A. Since

B. Once

C. Unless

D. While

答案：

A. Since

B. Once

C. Unless

(答案→)D. While

解析：考查让步状语从句。句意：尽管钢琴是她的主修，但是她也擅长弹吉他。A既然，自从；B一旦；C除非；D尽管。since引导原因状语从句或时间状语从句；once和unless表示条件；while在此表示让步。故选D。

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